|
KMID : 1103920080140040513
|
|
Korean Journal of Hepatology
2008 Volume.14 No. 4 p.513 ~ p.518
|
|
|
A case report of treatment with pegylated interferon alpha for Lamivudine-resistant chronic hepatitis B virus infection
|
|
Hur Won-Haing
Bae Si-Hyun
Yoon Seung-Gyu
Choi Jong-Young
You Chan-Ran
Jeong Soung-Won
Woo Hyun-Young
|
|
|
Abstract
|
|
|
|
The wide use of lamivudine in chronic hepatitis B has produced a monotonic increase in patients with lamivudine resistance. Therefore, treating lamivudine resistance in chronic hepatitis B is a major concern in clinical practice for the treatment of hepatitis B virus (HBV). There is conflicting evidence on the outcome of pegylated interferon alpha (PEG-IFN α) therapy against lamivudine-resistant HBV, which is due to mutations in the YMDD motif. We experienced a patient with chronic hepatitis B who was successfully treated with PEG-IFN α-2a after the development of virologic and biochemical breakthrough during lamivudine therapy. Virologic breakthrough was associated with the emergence of YMDD mutants 48 months after starting lamivudine therapy. Treatment with PEG-IFN α-2a for 12 months resulted in an undetectable serum level of HBV DNA and the resolution of hepatitis, and the virologic response was maintained over 16 months after cessation of PEG-IFN α-2a.
|
|
|
KEYWORD
|
|
|
Pegylated interferon alfa-2a, Lamivudine, YMDD motif mutant, Hepatitis B, Chronic
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|